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Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

DOI :

10.3791/58231-v

8:15 min

September 28th, 2018

September 28th, 2018

10,326 Views

1Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, U.S. Food and Drug Administration

A detailed protocol for the concurrent operation of 48 parallel cell cultures under varied conditions in a microbioreactor system is presented. Cell culture process, harvest and subsequent antibody titer analysis are described.

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High Throughput Automated Microbioreactor System

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