Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

12.0K Views

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15:04 min

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January 19th, 2019

DOI :

10.3791/58291-v

January 19th, 2019

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Meriem Bahri*¹, Julien Fleurence*¹, Sébastien Faraj*¹^,², Mohamed Ben Mostefa Daho*¹, Sophie Fougeray*¹^,³, Stéphane Birklé*¹^,³

¹Centre de Recherche en Cancérologie et Immunologie Nantes Angers (CRCINA), Institut national de la santé et de la recherche médicale (INSERM), Université d'Angers, Université de Nantes, Nantes, France, ²Service de chirurgie pédiatrique, Centre hospitalier universitaire (CHU) de Nantes, Nantes, France, ³Unité de Formation et Recherche (UFR) des Sciences Pharmaceutiques et Biologiques, Université de Nantes, Nantes, France

Summary

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Keywords Anticancer Antibody

Chapters in this video

0:00

Title

1:38

Evaluation of the Drug Interaction between mAb 8B6 and Topotecan in vitro

7:35

Generation of Human IMR5 Neuroblastoma Xenografts in NSG Mice

12:18

Representative Results

14:09

Conclusion

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