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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

DOI :

10.3791/58439-v

January 7th, 2019

January 7th, 2019

7,216 Views

1Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research

MALT1 regulates innate immunity but how this occurs remains ill-defined. We used the selective MALT1 paracaspase inhibitor MLT-827 to unravel the contribution of MALT1 to innate signaling downstream of Toll-like or C-type lectin-like receptors, demonstrating that MALT1 regulates the production of myeloid cytokines, and downstream of C-type lectin-like receptors, selectively.

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