JoVE Logo
Faculty Resource Center

Sign In

A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies

DOI :

10.3791/59631-v

8:04 min

January 24th, 2020

January 24th, 2020

11,460 Views

1Department of Ophthalmology, Stony Brook University, 2Department of Preventive Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc.

This article describes the development of a method to induce acute or chronic dry eye disease in rabbits by injecting concanavalin A to all portions of the orbital lacrimal gland system. This method, superior to those already reported, generates a reproducible, stable model of dry eye suitable for the study of pharmacological agents.

Tags

Rabbit Model

-- Views

Related Videos

article

Development of an Audio-based Virtual Gaming Environment to Assist with Navigation Skills in the Blind

article

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

article

Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice

article

Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI

article

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

article

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

article

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

article

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

article

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

article

Author Spotlight: Advancing Tear Fluid Analysis Using a Standardized Protocol for Proteomics Research

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved