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Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

DOI :

10.3791/60126-v

7:43 min

January 8th, 2020

January 8th, 2020

9,227 Views

1Department of Ophthalmology, Stony Brook University, 2Department of Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc, 4Department of Preventive Medicine, Stony Brook University

A novel approach is presented to induce chronic dry eye disease in rabbits by surgically removing all orbital lacrimal glands. This method, distinct from those previously reported, produces a stable, reproducible model of aqueous deficient dry eye well suited to study tear physiology and pathophysiology and ocular therapeutics.

Tags

Complete Dacryoadenectomy

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