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JoVE Journal
Biochemistry
This content is Open Access.
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
8.4K Views
•
15:05 min
•
May 20th, 2020
DOI :
May 20th, 2020
•Chapters in this video
0:04
Introduction
0:47
Structure Preparation
4:12
System Setup
5:17
Molecular Dynamics Simulation
7:15
Visual Inspection Analysis
8:29
Root-Mean Square Deviation (RMSD) and Root-Mean Square Fluctuation (RMSF) Analysis
9:58
Hydrogen Bond Analysis
10:57
Free Energy Calculations
12:25
Representative Results: Molecular Dynamics Simulation of EGFR Somatic Mutations
14:23
Conclusion
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ISSN 2578-2037
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