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Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound

DOI :

10.3791/61372-v

July 18th, 2020

July 18th, 2020

2,734 Views

1Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland

Presented here is a protocol to transiently open the blood-brain barrier (BBB) either focally or throughout a mouse brain to deliver fluorescently-labeled antibodies and activate microglia. Also presented is a method to detect the delivery of antibodies and microglia activation by histology.

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Keywords Antibodies

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