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A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

DOI :

10.3791/61606-v

8:40 min

August 7th, 2020

August 7th, 2020

5,552 Views

1Department of Medical Cell Biology, Uppsala University, 2Polymer Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University

This protocol presents a 3D biomimetic model with accompanying fibrotic stromal compartment. Prepared with physiologically relevant hydrogels in ratios mimicking the bio-physical properties of the stromal extracellular matrix, an active mediator of cellular interactions, tumor growth and metastasis.

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Biomimetic Model

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