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Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

DOI :

10.3791/61788-v

October 5th, 2020

October 5th, 2020

2,813 Views

1Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, 2Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center

The genetically tractable nematode Caenorhabditis elegans can be used as a simple and inexpensive model for drug discovery. Described here is a protocol to identify anticancer therapeutics that inhibit the downstream signaling of RAS and EGFR proteins.

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Keywords EGFR

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