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An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

DOI :

10.3791/62133-v

June 4th, 2021

June 4th, 2021

2,338 Views

1Department of Radiology, University of Chicago, 2Graduate Program in Medical Physics, University of Chicago

Histotripsy-aided lytic delivery or lysotripsy is under development for the treatment of deep vein thrombosis. An in vitro procedure is presented here to assess the efficacy of this combination therapy. Key protocols for the clot model, image guidance, and assessment of treatment efficacy are discussed.

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