Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
5.0K Views
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08:35 min
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May 29th, 2021
DOI :
May 29th, 2021
•Alice Douangamath*1,2, Ailsa Powell*1,2, Daren Fearon*1,2, Patrick M. Collins1,2, Romain Talon1,2,3, Tobias Krojer3,4, Rachael Skyner1,2, Jose Brandao-Neto1,2, Louise Dunnett1,2, Alexandre Dias1,2, Anthony Aimon1,2,3, Nicholas M. Pearce1,3, Conor Wild3,5, Tyler Gorrie-Stone1, Frank von Delft1,2,3,4,6
1Diamond Light Source Ltd, Harwell Science and Innovation Campus, 2Research Complex at Harwell, Harwell Science and Innovation Campus, 3Structural Genomics Consortium, University of Oxford, 4Centre for Medicines Discovery, University of Oxford, 5Oxford Protein Informatics Group, Department of Statistics, Oxford University, 6Department of Biochemistry, University of Johannesburg
Chapters in this video
0:04
Introduction
0:49
Fragment Screening Experiment
1:31
Crystal Soaking
2:27
Crystal Harvesting
3:31
Data Collection
4:02
Data Analysis
6:47
Results: XChem Screen of the Main Protease of SARS‐CoV‐2
7:59
Conclusion
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