Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
5.4K Views
•
06:29 min
•
March 3rd, 2021
DOI :
March 3rd, 2021
•Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1
1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin
Chapters in this video
0:04
Introduction
1:01
Soaking Crystals
3:14
Harvesting Crystals
4:46
Results: Photographic Snapshots of Some Crystalline Samples and Crystallographic Fragment Screening
5:55
Conclusion
Related Videos
06:58
Real-time Tracking of DNA Fragment Separation by Smartphone
14.5K Views
08:49
A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans
8.8K Views
08:29
Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies
11.3K Views
09:15
Synthesis of Ligand-free CdS Nanoparticles within a Sulfur Copolymer Matrix
9.4K Views
07:11
Measuring and Interpreting Oxygen Consumption Rates in Whole Fly Head Segments
15.6K Views
07:55
An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering
13.1K Views
09:19
NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
3.2K Views
09:00
A Sample Preparation Pipeline for Microcrystals at the VMXm Beamline
2.9K Views
06:26
Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
4.7K Views
08:34
Cryogenic Liquid Jets for High Repetition Rate Discovery Science
2.9K Views
Copyright © 2025 MyJoVE Corporation. All rights reserved