JoVE Logo
Faculty Resource Center

Sign In

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

DOI :

10.3791/64159-v

7:06 min

July 6th, 2022

July 6th, 2022

2,639 Views

1Institute of Biomedical and Environmental Health Research, University of the West of Scotland, 2Institute of Infection, Immunity and Inflammation, University of Glasgow

The present protocol describes the controlled microblade scratches on the surface of the articular cartilage after destabilizing the mouse knee by cutting the medial miniscotibial ligament. This animal model presents an accelerated form of osteoarthritis (OA) suitable for studying osteophyte formation, osteosclerosis, and early-stage pain.

Tags

Destabilization

-- Views

Related Videos

article

Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model

article

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

article

A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

article

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

article

Author Spotlight: Context Dependent Blood Collection Methods in Rats

article

Author Spotlight: Understanding the Mechanism of Tuina Manipulation in Rats

article

Analgesic Effect of Tuina on Rat Models with Compression of the Dorsal Root Ganglion Pain

article

A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

article

Author Spotlight: Investigating the Effectiveness of Tuina Therapy for Frozen Shoulder

article

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved