Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

1.0K Views

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08:41 min

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March 24th, 2023

DOI :

10.3791/64838-v

March 24th, 2023

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Anna Hadjihambi*¹^,², Rallia-Iliana Velliou*³, Panagiotis Tsialios⁴, Aigli-Ioanna Legaki³, Antonios Chatzigeorgiou*³, Maritina G. Rouchota*⁴

¹The Roger Williams Institute of Hepatology London, Foundation for Liver Research, ²Faculty of Life Sciences and Medicine, King's College London, ³Department of Physiology, Medical School, National and Kapodistrian University of Athens, ⁴BIOEMTECH, Lefkippos Attica Technology Park NCSR "Demokritos"

Summary

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In Vivo Micro Computed Tomography

NAFLD

Non invasive Imaging

Liver Disease Assessment

Hepatic Vascular Network

Contrast Agent Administration

Disease Progression Therapy

Chapters in this video

0:04

Introduction

1:06

Animal Preparation and Imaging Workflow

2:02

Evaluation of Hepatic Lipid Deposition/Steatosis

3:21

Functional Tissue Uptake/Lipid (Chylomicron) Transfer in the Liver

4:27

Architecture and Density of the Hepatic Vascular Network

5:32

Hepatic Relative Blood Volume

6:33

Results: Average Contrast Values and the Micro‐CT Imaging in Mice with NAFLD and Healthy Controls

7:50

Conclusion

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