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Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model

1.9K Views

09:03 min

March 10th, 2023

DOI :

10.3791/65113-v

March 10th, 2023


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Blood spinal Cord Barrier

Chapters in this video

0:04

Introduction

1:11

Low‐Intensity Focused Ultrasound Assembly and Setup

2:20

Animal Preparation and Surgical Laminectomy

3:38

Target Localization Using Laser Guidance

4:22

Microbubble Administration

5:27

Spinal Cord Extraction, Tissue Processing, and Visualization of BSCB Disruption

6:34

Results: Confirmation of Target Localization and Evaluating BSCB Disruption by EBD Extravasation into the Spinal Cord

8:17

Conclusion

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