We express our gratitude to the patients, surgeons, anesthesiologists, scrub nurses, and technicians who actively participated in this study. Without their cooperation, this research would not have been possible.

This prospective observational study, involving outpatient hysteroscopy surgery patients, was conducted from March to December 2023. It was approved by the hospital&#39;s ethics committee of Shanghai JiAi Genetics &#38; IVF Institute (ethics file number: JIAI E2020-09). All participants provided informed consent prior to inclusion in the study.
1. Patient selection and preparation
<ol>
	<li>Patient eligibility
	<ol>
		<li>Inclusion criteria: include patients with primary or secondary infertility, aged 18-45, with at least one transvaginal ultrasound suggesting uneven endometrial thickening or suspicion of endometrial polyps.</li>
		<li>Exclusion criteria: exclude individuals aged below 18 or above 45 years, those with severe internal medical comorbidities, unstable hemodynamics, acute pelvic inflammatory diseases, untreated infections, body temperature exceeding 37.5 &#176;C on the day of surgery, pregnant women, individuals with suspected endometrial or cervical cancer, uncontrolled hyperthyroidism, uterine enlargement with uterine cavity exceeding 12 cm, and those unwilling to provide informed consent.</li>
	</ol>
	</li>
	<li>Preoperative patient preparation
	<ol>
		<li>Perform a thorough assessment covering tests for hepatitis B, hepatitis C, human immunodeficiency virus (HIV), and syphilis, alongside evaluations such as an electrocardiogram, liver and kidney function tests, blood coagulation function analysis, complete blood count, vaginal discharge examination, and preoperative transvaginal ultrasound.</li>
		<li>Schedule surgery within 10 days following the cessation of menstrual bleeding. Prepare the following surgical instruments: a speculum, Hegar dilators, sponge holder, cervical forceps, sterilized gauze, probes, and curettes, as illustrated in Figure 1A.</li>
	</ol>
	</li>
</ol>
2. Surgical preparation
<ol>
	<li>Pre-operative preparation
	<ol>
		<li>Gather comprehensive medical history records encompassing the patient&#39;s age, obstetric and menstrual history, underlying medical conditions, history of uterine and abdominal procedures, and pertinent clinical symptoms such as irregular vaginal bleeding. Additionally, document uterine size, position (anteverted or retroverted), endometrial thickness, endometrial echo, and the presence of other uterine diseases such as uterine fibroids or adenomyosis through transvaginal ultrasound examinations during the follicular phase preceding the surgery.</li>
		<li>Determine the surgical risks to the patient and obtain their signed informed consent. Furthermore, prior to the surgical procedure, evaluate the patient&#39;s anesthesia risks, obtain their signed informed consent, and allow the patient to choose between local anesthesia and no anesthesia based on their individual condition.</li>
	</ol>
	</li>
	<li>Operation field
	<ol>
		<li>Ask the surgical team to be positioned as follows: the surgeon is situated at the foot of the patient, the first assistant stands to the right of the surgeon, the anesthesiologist is located on the left side at the head end of the patient, and the scrub nurse is positioned on the left side of the patient (refer to Figure 1B).</li>
		<li>Position the endoscopic equipment on the right side at the foot of the patient, place the anesthesia equipment on the right side at the head end of the patient, and situate the monitoring equipment at the head end of the patient. Place the patient in the lithotomy position, with the lower legs secured by bandages on both sides to ensure immobilization during the procedure.</li>
	</ol>
	</li>
	<li>Disinfection
	<ol>
		<li>Perform disinfection according to the principle of disinfecting from top to bottom and inside to outside. Use iodine gauze to disinfect the external genitalia, labia, perineum, inner thighs, and perianal skin three times. Perform iodine gauze disinfection of the vagina 3 times. Complete the surgical draping with sterile surgical drapes.</li>
	</ol>
	</li>
</ol>
3. Surgical procedure
<ol>
	<li>Perform the following tasks as per the personnel&#39;s specialization: the anesthesiologist establishes peripheral venous access; the primary surgical assistant is responsible for assembling the hysteroscope lens, cleaning the lens, adjusting focus, and setting the white balance. 
	NOTE: All surgeries are performed using a 5.2-mm-diameter hysteroscope by the same experienced hysteroscopic surgeon.</li>
	<li>Set the hysteroscope pressure at 100 mmHg, with a flow rate of 300 mL/min. Use 0.9% saline solution as the distension media. Evacuate gas from the uterine cavity using the hysteroscope. Use cervical forceps to grasp the lower right lip of the cervix and carry out iodine disinfection again for the vagina, fornix, and cervix.</li>
	<li>Introduce the hysteroscope into the uterine cavity through the cervical canal. In case of encountering difficulties, retract the hysteroscope and use a measuring probe with a scale to evaluate the uterine cavity&#39;s positioning and depth. Then, pull the cervical clamp to flatten the overly curved uterus to facilitate the hysteroscope to enter the uterine cavity.</li>
	<li>Perform cervical dilation using Hegar dilators ranging from No. 3.5 to No. 5.5. Administer Phloroglucinol (80 mg intravenous injection) to relax the cervical smooth muscle if required.</li>
	<li>Keep detailed records during hysteroscopy surgeries upon introducing the hysteroscope into the uterine cavity, documenting the presence or absence of endometrial polyps, along with their location, size, morphology (pedunculated or broad-based), and any other notable endometrial conditions.</li>
	<li>Polyp removal
	<ol>
		<li>For patients with a single uterine polyp, perform the following steps.
		<ol>
			<li>Carry out individual removal using micro-forceps. Use the blunt end of the micro-forceps to pinpoint the basal layer of the endometrium (refer to Figure 2A). An anatomical gap exists between the endometrial polyp and the basal layer (as illustrated in Figure 2B); place the forceps here to grasp the basal portion of the endometrial polyp.</li>
			<li>Swiftly withdraw the micro-forceps to ensure complete separation of the polyp base from the endometrial base (as depicted in Figure 2C). Carry out the procedure incrementally until the polyp is entirely excised. Collect the excised polyp tissue for pathological examination. The typical pre- and post-operative images are shown in Figure 3A, B.</li>
		</ol>
		</li>
		<li>For patients with multiple endometrial polyps, perform the following steps.
		<ol>
			<li>In patients presenting with multiple endometrial polyps causing obstructive effects during surgery, employ micro-scissors initially to excise most of the polyps (refer to Figure 2D). This strategy is intended to increase the surgical space and enhance visibility within the operative field. Following this, remove any remaining polyp bases utilizing step 3.6.1. 
			NOTE: Special caution should be exercised when using micro-scissors to avoid cutting too deeply during the procedure to prevent injury to the basal layer of the endometrium.</li>
			<li>Start the sequence for polyp excision with the posterior uterine wall, followed by the uterine lateral wall and corners, and then the anterior uterine wall. This surgical order is designed to optimize the clarity of the surgical field.</li>
			<li>Once the complete excision of all polyp bases is confirmed, withdraw the hysteroscope and use a small curette or sponge forceps to ensure complete removal of the polyp tissue. The typical pre- and post-operative images are shown in Figure 3C-E. 
			NOTE: To minimize the heightened risk of infection associated with repeated hysteroscope insertions, it is generally advisable not to conduct further hysteroscopic exploration after the tissue removal.</li>
		</ol>
		</li>
	</ol>
	</li>
	<li>Following the retrieval of all surgical instruments, clean the cervix and vagina by iodine disinfection.</li>
</ol>
4. Postoperative procedures
<ol>
	<li>Following the surgical procedure, thoroughly document all observations and surgical interventions performed. After this, submit the specimens for pathological evaluation.</li>
	<li>Carry out postoperative monitoring for 1 h to assess the patient&#39;s condition. In the absence of any complications, discharge patients without the need for additional medication. 
	NOTE: The surgery process does not require any electronic devices and only requires the use of micro-scissors and micro-forceps. If electronic devices are used during surgery, it will be documented as a failure of the surgical procedure. All surgical complications should be documented, and postoperative pathological reports should also be recorded.</li>
</ol>
5. Statistical analysis
<ol>
	<li>For quantitative data, use descriptive statistics such as mean, standard deviation, median, and confidence interval; for qualitative data, use frequency and percentage for description.</li>
</ol>

Hysteroscopic Technique with Micro-Scissors and Forceps for Polyp Removal

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The authors declare no competing interests.

Our research presents a novel surgical technique for removing endometrial polyps without cutting or causing electrical damage to the uterine endometrium, which is especially beneficial for women with fertility concerns. Sharon et al. introduced a similar technique using a non-electric loop for polyp excision11, demonstrating its efficacy and safety. However, the traditional resectoscope has a larger diameter12, necessitating cervical dilation and potentially increasing the ...

Endometrial polyps are abnormal tissue growths in the uterine lining with significant implications for fertility and reproductive health1. The estimated incidence rate of endometrial polyps is approximately 35% among patients with infertility2, though this figure may vary. These polyps can disrupt embryo implantation by inducing structural deformities in the uterine cavity and impacting the endometrium&#39;s ability to support implantation3,4,5,6. While hysteroscopic surgery is a common procedure for removing endometrial polyps, it is not without risks, with uterine perforation being the primary complication, particularly during the removal of multiple polyps7. Hysteroscopy with resectoscopes and classic mechanical resection with scissors and/or graspers remain standard for evaluating and treating the pathology of the cervical canal and endometrial cavity8. The application of electric energy during the procedure can result in endometrial damage, especially in cases involving anatomical variations such as a unicornuate uterus9. Mechanical technology such as morcellators and scissors are less painful than electrical devices when eliminating structural lesions in the office10.
In response to these challenges, a novel approach is proposed involving the combined use of micro-scissors and forceps during hysteroscopy. This technique aims to minimize the risk of injury to the endometrium, particularly the basal layer while ensuring the complete excision of polyps to enhance fertility outcomes for women. The technique is easy to learn and requires two doctors to perform the operation. Doctors with experience in hysteroscopy are capable of executing this procedure. It is a new and unique technique that eliminates thermal damage in a very common gynecologic indication.
Overall, this innovative approach presents a safer and more precise method for eliminating endometrial polyps, particularly in women with fertility concerns, offering a valuable alternative to traditional hysteroscopic procedures and potentially enhancing outcomes for patients requiring treatment for endometrial polyps.

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Grasping Forceps</td>
			<td>ShenDa</td>
			<td>X5164B</td>
			<td></td>
		</tr>
		<tr>
			<td>Hysteroscope Lens</td>
			<td>ShenDa</td>
			<td>J0122A</td>
			<td></td>
		</tr>
		<tr>
			<td>Hysteroscopic Infusion Set</td>
			<td>ShenDa</td>
			<td>T7511&#160;</td>
			<td></td>
		</tr>
		<tr>
			<td>IMAGE 1 S CONNECT</td>
			<td>KARL STORZ</td>
			<td>TC200</td>
			<td></td>
		</tr>
		<tr>
			<td>IMAGE1 HD</td>
			<td>KARL STORZ</td>
			<td>H3-Z</td>
			<td></td>
		</tr>
		<tr>
			<td>IMAGE1 S H3-LINK</td>
			<td>KARL STORZ</td>
			<td>TC300</td>
			<td></td>
		</tr>
		<tr>
			<td>Monitor</td>
			<td>NDS surgical imaging, LLC</td>
			<td>N-90X0568-G</td>
			<td></td>
		</tr>
		<tr>
			<td>Optical Cable</td>
			<td>ShenDa</td>
			<td>U8724</td>
			<td></td>
		</tr>
		<tr>
			<td>Scissors</td>
			<td>ShenDa</td>
			<td>X5261A&#160;</td>
			<td></td>
		</tr>
		<tr>
			<td>Sealing Cap</td>
			<td>ShenDa</td>
			<td>T7303</td>
			<td></td>
		</tr>
		<tr>
			<td>Uterine Balloon Dilator</td>
			<td>ShenDa</td>
			<td>U9522 DG-1</td>
			<td></td>
		</tr>
		<tr>
			<td>XENON NOVA 300</td>
			<td>KARL STORZ</td>
			<td>201340 20</td>
			<td></td>
		</tr>
	</tbody>
</table>

improved hysteroscopic resection of endometrial polyps using 6-fr micro-scissors and forceps

Endometrial polyps commonly contribute to female infertility, and hysteroscopic resection is the established surgical approach for their treatment. Numerous resection methods are available, with the most used and cost-effective options being cold resection employing micro-scissors or hot resection using an electric loop. However, both methods involve sharp resection, posing a challenge in achieving complete polyp removal while avoiding damage to the uterine endometrium. To address this issue, this study proposes an innovative approach: the combined use of the 6 Fr micro-scissors and forceps under hysteroscopy. The method entails utilizing 6 Fr micro-scissors to initially remove large polyps, followed by using 6 Fr micro-forceps to extract the remaining polyp tissue expeditiously and bluntly near the basal layer of the endometrium. This approach not only prevents surgical damage to the basal layer of the endometrium but also mitigates the risk of residual polyps resulting from incomplete resection. This method is particularly suitable for women with fertility requirements, offering additional considerations for the selection of treatment options for endometrial polyp resection.

Author Spotlight: A Reproductive Hysteroscopy Approach for Complete Endometrial Polyp Removal and Enhanced Endometrial Receptivity

Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps

Our research is mainly about reproductive hysteroscopy, and the main problem we want to solve is how to ensure that the uterine environment of endometrial patients achieves optimal pregnancy conditions. The main challenge now is how to completely remove endometrial polyps while protecting the patient's fertility and not damaging the basal layer of the endometrium. Our surgical protocol can ensure the total removal of polyps and at the same time maximize the patient's endometrial receptivity in order to improve the patient's fertility.

A total of 114 patients suspected of having endometrial polyps based on transvaginal ultrasound findings participated in this study (Figure 4). All patients underwent hysteroscopy, with 15 patients diagnosed without endometrial polyps. The remaining 99 patients underwent endometrial polyp resection using the hysteroscopy technique. Among these 99 patients, aged between 26 and 44 years (Table 1), the average parity was 0.54 &#177; 0.78, and the median diameter of endometrial ...

The novel technique presented here employs a combination of 6-Fr micro-scissors and forceps for hysteroscopic treatment of endometrial polyps, demonstrating encouraging outcomes for infertile patients afflicted with this condition.

Endometrial polyps commonly contribute to female infertility, and hysteroscopic resection is the established surgical approach for their treatment. ...

improved-hysteroscopic-resection-endometrial-polyps-using-6-fr-micro

Research

JoVE Journal

Medicine

284 Views.  Shanghai Geriatrics Medical Center. Our research is mainly about reproductive hysteroscopy, and the main problem we want to solve is how to ensure that the uterine environment of endometrial patients achieves optimal pregnancy conditions. The main challenge now is how to completely remove endometrial polyps while protecting the patient's fertility and not damaging the basal layer of the endometrium. Our surgical protocol can ensure the total removal of polyps and at the same time maximize the patient's endometrial receptivity i...