Plating TUM622 Cells in the Extracellular Matrix for 3D Culturing
3:52
3D Coculturing of TUM622 Cells and CAFs (Cancer Associated Fibroblasts) in the Extracellular Matrix
5:39
Results: Growth and Morphology
6:58
Conclusion
Transcript
Our culture system captures the phenotypic plasticity of lung squamous cell carcinoma cells in response to tumor-stroma interactions and how these interactions regulate tumor morphology during lung squamous cell carcinoma progression. The main adv
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An in vitro model system was developed to capture tissue architectural changes during lung squamous carcinoma (LUSC) progression in a 3-dimensional (3D) co-culture with cancer-associated fibroblasts (CAFs). This organoid system provides a unique platform to investigate the roles of diverse tumor cell-intrinsic and extrinsic changes that modulate the tumor phenotype.
