In vivo Time-lapse Imaging and Intravenous Antibody Administration
8:51
Results: Representative In Situ Adoptively Trabsferred Effector T Cell Imaging
10:12
Conclusion
Transkript
The overall goal of this imaging protocol is to visualize CD4 positive T Cell dynamics in the inflamed skin. This method can help answer key questions in the field of immunology, such as, what are the mechanisms that underlie immune cell motility,
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The mechanisms that govern the interstitial motility of CD4 effector T cells at sites of inflammation are relatively unknown. We present a non-invasive approach to visualize and manipulate in vitro-primed CD4 T cells in the inflamed ear dermis, allowing for study of the dynamic behavior of these cells in situ.