The overall goal of this technique is to generate three dimensional engineered heart tissue that can be used as an in vitro contraction analysis platform for drug screening and disease modeling. This method can help answer key questions in the car
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Here, we show the generation of human engineered heart tissue from induced pluripotent stem cells (hiPSC)-derived cardiomyocytes. We present a method to analyze contraction force and exemplary alteration of contraction pattern by the hERG channel inhibitor E-4031. This method shows high level of robustness and suitability for cardiac drug screening.