Clear cell renal cell carcinoma or CCRCC, is the most common subtype of kidney cancer. Localize CCRCC has favorable outcome with surgery. However, one third of CCRCC patients will develop distant metastasis to the lung.
Which leads to a very
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Metastatic clear cell renal cell carcinoma is a disease without a comprehensive animal model for thorough preclinical investigation. This protocol illustrates two novel animal models for the disease: the orthotopically implanted mouse model and the chicken chorioallantoic membrane model, both of which demonstrate lung metastasis resembling clinical cases.