Pre-Conditioning/Pre-Exposure and Fear Conditioning
4:20
Fear Recall and Fear Extinction
5:13
Behavior Quantification
7:00
Results: Representative Freezing and Flight Behavior Analyses
8:49
Conclusion
Transcription
The overall aim of this paradigm is to assess complex defensive behavior in rodents. This protocol is significant because it facilitates investigations into the transitions between defensive behaviors, making it ideal for researchers interested in
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Defensive behavioral responses are contingent upon threat intensity, proximity, and context of exposure. Based on these factors, we developed a classical conditioning paradigm that elicits clear transitions between conditioned freezing and flight behavior within individual subjects. This model is crucial for the understanding the pathologies involved in anxiety, panic, and post-traumatic stress disorders.