Measurement of Magnitudes of Accelerations and Adjustment of the PHM System
1:33
Quantification of Mouse Head-Twitch Response
2:03
Immunohistochemical Analysis of Prefrontal Cortex (PFC) Collected from Euthanized Mouse Brain
3:22
Results: Effect of Treadmill Running and PHM Application in Mouse PFC Neurons
4:37
Conclusion
Transcription
Our protocol helps answer the questions of how physical exercise supports organism homeostasis. The systems allowed us to dissect direct mechanical effects on the brain from complex consequences of physical activities such as walking and jogging.
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The present protocol describes a custom-designed ''passive head motion'' system, which reproduces mechanical accelerations at rodents' heads generated during their treadmill running at moderate velocities. It allows dissecting mechanical factors/elements from the beneficial effects of physical exercise.