Department of Pharmaceutical Chemistry,
Tetrad Graduate Program,
Center for Systems and Synthetic Biology,
Chemistry and Chemical Biology Graduate Program
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Multistep small-molecule synthesis programmed by DNA templates.
Journal of the American Chemical Society Sep, 2002 | Pubmed ID: 12197733
Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis.
Angewandte Chemie (International ed. in English) Nov, 2002 | Pubmed ID: 12412096
Two enabling architectures for DNA-templated organic synthesis.
Angewandte Chemie (International ed. in English) Mar, 2003 | Pubmed ID: 12671971
Translation of DNA into synthetic N-acyloxazolidines.
Journal of the American Chemical Society Apr, 2004 | Pubmed ID: 15099091
Directed evolution of ligand dependence: small-molecule-activated protein splicing.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2004 | Pubmed ID: 15247421
DNA-templated organic synthesis and selection of a library of macrocycles.
Science (New York, N.Y.) Sep, 2004 | Pubmed ID: 15319493
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19273855
Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns.
Langmuir : the ACS journal of surfaces and colloids Jun, 2009 | Pubmed ID: 19505164
Expanding the reaction scope of DNA-templated synthesis.
Angewandte Chemie (International ed. in English) May, 2002 | Pubmed ID: 19750721
Chemically programmed cell adhesion with membrane-anchored oligonucleotides.
Journal of the American Chemical Society Jan, 2012 | Pubmed ID: 22176556
Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences.
Langmuir : the ACS journal of surfaces and colloids May, 2012 | Pubmed ID: 22512362
Programmed Cell-to-Cell Variability in Ras Activity Triggers Emergent Behaviors during Mammary Epithelial Morphogenesis.
Cell reports Oct, 2012 | Pubmed ID: 23041312
Directing the assembly of spatially organized multicomponent tissues from the bottom up.
Trends in cell biology Dec, 2012 | Pubmed ID: 23067679
Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging.
PloS one , 2013 | Pubmed ID: 23762287
Formation of targeted monovalent quantum dots by steric exclusion.
Nature methods Dec, 2013 | Pubmed ID: 24122039
A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds.
Journal of the American Chemical Society Aug, 2014 | Pubmed ID: 25029632
Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding.
Tissue engineering. Part C, Methods Jun, 2015 | Pubmed ID: 25351430
A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2015 | Pubmed ID: 25633040
Programmed synthesis of three-dimensional tissues.
Nature methods Oct, 2015 | Pubmed ID: 26322836
Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances.
Integrative biology : quantitative biosciences from nano to macro Dec, 2015 | Pubmed ID: 26507156
A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time.
Cell Jun, 2016 | Pubmed ID: 27180907
Dissecting the stem cell niche with organoid models: an engineering-based approach.
Development (Cambridge, England) 03, 2017 | Pubmed ID: 28292846
Non-autonomous cell proliferation in the mammary gland and cancer.
Current opinion in cell biology 04, 2017 | Pubmed ID: 28314237
A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.
Cell 03, 2017 | Pubmed ID: 28340336
Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells.
Proceedings of the National Academy of Sciences of the United States of America 08, 2017 | Pubmed ID: 28760972
Opportunities for organoids as new models of aging.
The Journal of cell biology 01, 2018 | Pubmed ID: 29263081
Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.
Developmental cell 01, 2018 | Pubmed ID: 29290586
Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.
Cell reports 03, 2018 | Pubmed ID: 29514089
Quanti.us: a tool for rapid, flexible, crowd-based annotation of images.
Nature methods 08, 2018 | Pubmed ID: 30065368
DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors.
Cell systems 04, 2019 | Pubmed ID: 30954475
MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices.
Nature methods 07, 2019 | Pubmed ID: 31209384
Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.
Antibodies (Basel, Switzerland) Nov, 2019 | Pubmed ID: 31694242
Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development.
Developmental cell Dec, 2019 | Pubmed ID: 31794715
Linked optical and gene expression profiling of single cells at high-throughput.
Genome biology 02, 2020 | Pubmed ID: 32093753
Organoid models for mammary gland dynamics and breast cancer.
Current opinion in cell biology 10, 2020 | Pubmed ID: 32535255
ZipSeq: barcoding for real-time mapping of single cell transcriptomes.
Nature methods 08, 2020 | Pubmed ID: 32632238
Roadmap on multiscale coupling of biochemical and mechanical signals during development.
Physical biology Dec, 2020 | Pubmed ID: 33276350
Guiding tissue-scale self-organization.
Nature materials Jan, 2021 | Pubmed ID: 33340008
No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells.
BMC biology Jan, 2021 | Pubmed ID: 33472616
Expanding the boundaries of synthetic development.
Developmental biology Feb, 2021 | Pubmed ID: 33587913
Daeha Seo*,1,2,3,
Justin Farlow*,4,5,6,
Kade Southard1,4,7,
Young-wook Jun1,7,
Zev J. Gartner4,5,6,7
1Department of Otolaryngology, University of California, San Francisco,
2Department of Chemistry, University of California, Berkeley,
3Materials Science Division, Lawrence Berkeley National Laboratory,
4Department of Pharmaceutical Chemistry, University of California, San Francisco,
5Tetrad Graduate Program, University of California, San Francisco,
6Center for Systems and Synthetic Biology, University of California, San Francisco,
7Chemistry and Chemical Biology Graduate Program, University of California, San Francisco
Katelyn A. Cabral1,
David M. Patterson2,
Olivia J. Scheideler1,
Russell Cole3,
Adam R. Abate4,5,6,
David V. Schaffer7,8,
Lydia L. Sohn9,
Zev J. Gartner2,6,10
1Graduate Program in Bioengineering, University of California San Francisco and University of California Berkeley,
2Department of Pharmaceutical Chemistry, University of California San Francisco,
3, Scribe Biosciences,
4Department of Bioengineering and Therapeutic Sciences, University of California San Francisco,
5California Institute for Quantitative Biosciences, University of California San Francisco,
6Chan Zuckerberg Biohub, University of California San Francisco,
7Department of Chemical & Biomolecular Engineering, University of California Berkeley,
8Helen Wills Neuroscience Institute, University of California Berkeley,
9Department of Mechanical Engineering, University of California Berkeley,
10Center for Cellular Construction, University of California San Francisco
1Department of Bioengineering and Therapeutic Sciences, University of California San Francisco,
2University of California Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco,
3Department of Pharmaceutical Chemistry, University of California San Francisco,
4California Institute for Quantitative Biosciences, University of California San Francisco,
5, Chan Zuckerberg Biohub