JoVE Journal

Medicine

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Mouse Pneumonectomy Model of Compensatory Lung Growth

12.6K Views

09:22 min

December 17th, 2014

December 17th, 2014

12,559 Views

0:05

Title

1:32

Preparation for Surgery

2:03

Mouse Oro-Tracheal Intubation and Mechanical Ventilation

2:52

Mouse Pneumonectomy (PNX)

6:13

Mouse Sham Pneumonectomy

7:15

Post-surgical Procedures

8:02

Results: Expected Weight Loss After Pneumonectomy (PNX)

8:56

Conclusion

Mouse pneumonectomy is a commonly employed model of compensatory lung growth. This procedure can be used in conjunction with lineage tracing or transgenic mouse models to elucidate underlying mechanisms.

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