The overall goal of this surgical procedure is to induce dilated cardiomyopathy and provide a stable platform for studying pathophysiology of chronic heart failure including remodeling and excentric ventricular hypertrophy. This method can help to
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Here, we present a protocol to produce tachycardia-induced cardiomyopathy in swine. This model represents a potent way to study the hemodynamics of progressive chronic heart failure and the effects of applied treatment.