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JoVE Journal

Neuroscience

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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

3.4K Views

05:51 min

October 14th, 2021

October 14th, 2021

3,409 Views

0:04

Introduction

0:54

Preparation of Reagents and Supplies and Cage Setup

3:15

Levodopa-Induced Dyskinesia Rating Post-Injection

4:04

Results: L-DOPA-Induced Dyskinesias (LID) Assessment in the Parkinsonian Rats

5:06

Conclusion

필기록

Our protocol provides a detailed method for a reliable induction and comprehensive rating of levodopa-induced dyskinesia in a rat model of Parkinson's disease. The main advantage of our dyskinesia rating scale is that it allows for quantification

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This article describes methods to induce and evaluate levodopa-induced dyskinesias in a rat model of Parkinson's disease. The protocol offers detailed information regarding the intensity and frequency of a range of dyskinetic behaviors, both dystonic and hyperkinetic, providing a reliable tool to test treatments targeting this unmet medical need.

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