We thank the anaesthesiologists and operating room nurses who assisted with the operation.

This protocol follows the guidelines of the human research ethics committee of the Sixth Affiliated Hospital, Sun Yat-sen University. Written informed consent was obtained from the patients for performing this study.
NOTE: A 48-year-old female patient presented with an incidental finding of a 3.0 cm x 2.5 cm asymptomatic mass in the head of the pancreas. The patient&#39;s clinical history showed a healthy status. Endoscopic ultrasound (EUS) showed a cystic lesion of the pancreatic head.
<p...

<ol>
	<li>Mihaljevic, A. L., Kleeff, J., Friess, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Beger's+operation+and+the+Berne+modification:+Origin+and+current+results.">Beger's operation and the Berne modification: Origin and current results.</a> J Hepatobiliary Pancreat Sci. 17 (6), 735-744 (2010).</li><li>Beger, H. G., Schlosser, W., Friess, H. M., B&#252;chler, M. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenum-preserving+head+resection+in+chronic+pancreatitis+changes+the+natural+course+of+the+disease:+A+single-center+26-year+experience.">Duodenum-preserving head resection in chronic pancreatitis changes the natural course of the disease: A single-center 26-year experience.</a> Ann Surg. 230 (4), 512-519 (1999).</li><li>D'haese, J. G., Ceyhan, G. O., Demir, I. E., Tieftrunk, E., Friess, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Treatment+options+in+painful+chronic+pancreatitis:+A+systematic+review.">Treatment options in painful chronic pancreatitis: A systematic review.</a> HPB (Oxford). 16 (6), 512-521 (2014).</li><li>Beger, H. G., Rau, B. M., Gansauge, F., Poch, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenum-preserving+subtotal+and+total+pancreatic+head+resections+for+inflammatory+and+cystic+neoplastic+lesions+of+the+pancreas).">Duodenum-preserving subtotal and total pancreatic head resections for inflammatory and cystic neoplastic lesions of the pancreas).</a> J Gastrointest Surg. 12 (6), 1127-1132 (2008).</li><li>Beger, H. G., B&#252;chler, M., Bittner, R. R., Oettinger, W., Roscher, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenum-preserving+resection+of+the+head+of+the+pancreas+in+severe+chronic+pancreatitis.+Early+and+late+results.">Duodenum-preserving resection of the head of the pancreas in severe chronic pancreatitis. Early and late results.</a> Ann Surg. 209 (3), 273-278 (1989).</li><li>Beger, H. G., Nakao, A., Mayer, B., Poch, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenum-preserving+total+and+partial+pancreatic+head+resection+for+benign+tumors--systematic+review+and+meta-analysis.">Duodenum-preserving total and partial pancreatic head resection for benign tumors--systematic review and meta-analysis.</a> Pancreatology. 15 (2), 167-178 (2015).</li><li>Cao, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Laparoscopic+duodenum-preserving+total+pancreatic+head+resection:+A+novel+surgical+approach+for+benign+or+low-grade+malignant+tumors.">Laparoscopic duodenum-preserving total pancreatic head resection: A novel surgical approach for benign or low-grade malignant tumors.</a> Surg Endosc. 33 (2), 633-638 (2019).</li><li>Loomba, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Randomized,+controlled+trial+of+the+fgf21+analogue+pegozafermin+in+nash.">Randomized, controlled trial of the fgf21 analogue pegozafermin in nash.</a> N Engl J Med. 389 (11), 998-1008 (2023).</li><li>Lu, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Laparoscopic+duodenum-preserving+pancreatic+head+resection+with+real-time+indocyanine+green+guidance+of+different+dosage+and+timing:+Enhanced+safety+with+visualized+biliary+duct+and+its+long-term+metabolic+morbidity.">Laparoscopic duodenum-preserving pancreatic head resection with real-time indocyanine green guidance of different dosage and timing: Enhanced safety with visualized biliary duct and its long-term metabolic morbidity.</a> Langenbecks Arch Surg. 407 (7), 2823-2832 (2022).</li><li>Huang, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Real-time+fluorescence+imaging+with+indocyanine+green+during+laparoscopic+duodenum-preserving+pancreatic+head+resection.">Real-time fluorescence imaging with indocyanine green during laparoscopic duodenum-preserving pancreatic head resection.</a> Pancreatology. , (2023).</li><li>Hong, D., Cheng, J., Wu, W., Liu, X., Zheng, X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=How+to+perform+total+laparoscopic+duodenum-preserving+pancreatic+head+resection+safely+and+efficiently+with+innovative+techniques.">How to perform total laparoscopic duodenum-preserving pancreatic head resection safely and efficiently with innovative techniques.</a> Ann Surg Oncol. 28 (6), 3209-3216 (2021).</li><li>Zhou, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Laparoscopic+duodenum-preserving+pancreatic+head+resection:+A+case+report.">Laparoscopic duodenum-preserving pancreatic head resection: A case report.</a> Medicine (Baltimore). 95 (32), 4442 (2016).</li><li>Alvarado-Bachmann, R., Choi, J., Gananadha, S., Hugh, T. J., Samra, J. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+infracolic+approach+to+pancreatoduodenectomy+for+large+pancreatic+head+tumours+invading+the+colon.">The infracolic approach to pancreatoduodenectomy for large pancreatic head tumours invading the colon.</a> Eur J Surg Oncol. 36 (12), 1220-1224 (2010).</li><li>Diener, M. K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenum-preserving+pancreatic+head+resection+versus+pancreatoduodenectomy+for+surgical+treatment+of+chronic+pancreatitis:+A+systematic+review+and+meta-analysis.">Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for surgical treatment of chronic pancreatitis: A systematic review and meta-analysis.</a> Ann Surg. 247 (6), 950-961 (2008).</li><li>Beger, H. G., Mayer, B., Poch, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenum-preserving+pancreatic+head+resection+for+benign+and+premalignant+tumors-a+systematic+review+and+meta-analysis+of+surgery-associated+morbidity.">Duodenum-preserving pancreatic head resection for benign and premalignant tumors-a systematic review and meta-analysis of surgery-associated morbidity.</a> J Gastrointest Surg. 27 (11), 2611-2627 (2023).</li><li>Chen, X., Chen, W., Zhang, Y., An, Y., Zhang, X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Short-term+outcomes+of+laparoscopic+duodenum-preserving+total+pancreatic+head+resection+compared+with+laparoscopic+pancreaticoduodenectomy+for+the+management+of+pancreatic-head+benign+or+low-grade+malignant+lesions.">Short-term outcomes of laparoscopic duodenum-preserving total pancreatic head resection compared with laparoscopic pancreaticoduodenectomy for the management of pancreatic-head benign or low-grade malignant lesions.</a> Med Sci Monit. 26, e927248 (2020).</li><li>Takada, T., Yasuda, H., Amano, H., Yoshida, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+duodenum-preserving+and+bile+duct-preserving+total+pancreatic+head+resection+with+associated+pancreatic+duct-to-duct+anastomosis.">A duodenum-preserving and bile duct-preserving total pancreatic head resection with associated pancreatic duct-to-duct anastomosis.</a> J Gastrointest Surg. 8 (2), 220-224 (2004).</li><li>Li, X. L., Gong, L. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Preoperative+3d+reconstruction+and+fluorescent+indocyanine+green+for+laparoscopic+duodenum+preserving+pancreatic+head+resection:+A+case+report.">Preoperative 3d reconstruction and fluorescent indocyanine green for laparoscopic duodenum preserving pancreatic head resection: A case report.</a> World J Clin Cases. 11 (4), 903-908 (2023).</li><li>Vlek, S. L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Biliary+tract+visualization+using+near-infrared+imaging+with+indocyanine+green+during+laparoscopic+cholecystectomy:+Results+of+a+systematic+review.">Biliary tract visualization using near-infrared imaging with indocyanine green during laparoscopic cholecystectomy: Results of a systematic review.</a> Surg Endosc. 31 (7), 2731-2742 (2017).</li><li>Cai, Y., Zheng, Z., Gao, P., Li, Y., Peng, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Laparoscopic+duodenum-preserving+total+pancreatic+head+resection+using+real-time+indocyanine+green+fluorescence+imaging.">Laparoscopic duodenum-preserving total pancreatic head resection using real-time indocyanine green fluorescence imaging.</a> Surg Endosc. 35 (3), 1355-1361 (2021).</li></ol>

The authors report no conflict of interest.

LDPPHR only removes the diseased pancreatic head while preserving the duodenum, stomach, jejunum, common bile duct, and gallbladder that need to be removed in Whipple surgery. Compared to pancreaticoduodenectomy (PD) and pylorus-preserving pancreaticoduodenectomy (PPPD), LDPPHR showed enhancements in mid- and long-term results encompassing hospital stay duration, quality of life, post-surgery recovery, and maintenance of exocrine function5,14. DPPHR only removes ...

In 1972, Prof. Berger first proposed the duodenum-preserving pancreatic head resection (DPPHR) and Roux-en-Y pancreatic-enteral reconstruction as a treatment for chronic pancreatitis1. DPPHR has become the primary surgical treatment for benign lesions of the pancreatic head due to its low incidence of postoperative complications and mortality, as well as its ability to maintain the endocrine and exocrine functions of the pancreas and high remission rate of abdominal pain2,3,4. DPPHR only removes the diseased pancreatic head while preserving the duodenum, stomach, jejunum, common bile duct, and gallbladder that need to be removed in Whipple surgery, resulting in minimal damage and high postoperative quality of life3,5.
Laparoscopic duodenum-preserving pancreatic head resection (LDPPHR) has made significant progress in the last decade and is gradually replacing duodenum-preserving pancreatic head resection (DPPHR)6,7. The key to this surgical procedure is to ensure the blood supply of the duodenum and bile duct in order to avoid damage to the duodenum and bile duct, as well as duodenal necrosis and stenosis or atresia of the bile duct caused by ischemia7,8.&#160;A few experienced medical centers have reported LDPPHR9,10,11. As maintaining the integrity of the duodenum and biliary system and preserving complex blood supplies are necessary, the surgical procedure is challenging. It is essential to be very familiar with the special anatomical relationship between the pancreatic head and the duodenum while implementing LDPPHR, which is a difficult surgery that requires stronger surgical skills and psychological qualities.
Previous studies have proved that preserving the integrity of both anterior and posterior pancreaticoduodenal arterial arcades, as well as only preserving the posterior collateral branches of the arteries, will not cause duodenal ischemic necrosis11,12. Some surgeons preserve a thin layer of pancreatic tissue adhering to the common bile duct to avoid ischemia of the bile duct and duodenum but increase the incidence of pancreatic fistula13. In this study, the inferior infracolic approach was chosen for LDPPHR due to the patient with a thin mesenteric fat layer. By taking advantage of the amplification of the 3D laparoscopy, we successfully removed the pancreas from the lateral wall of the common bile duct (CBD) and the medial side of the duodenal ring without intraoperative fluorescence image guidance. This approach ensured the integrity of the vascular arch and reduced intraoperative blood loss, thereby minimizing the risk of pancreatic fistula.

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>3D Laparoscope</td>
			<td>STORZ</td>
			<td>TC200,TC302</td>
			<td></td>
		</tr>
		<tr>
			<td>Cisatracurium Besylate Injection</td>
			<td>Hengrui Pharma</td>
			<td>H20183042</td>
			<td></td>
		</tr>
		<tr>
			<td>Drainage catheters</td>
			<td>Jiangsu YUBANG MED-DEVICE</td>
			<td>YB-B-III</td>
			<td></td>
		</tr>
		<tr>
			<td>Harmonic ACE Ultrasonic Surgical Devices</td>
			<td>Ethicon Endo-Surgery</td>
			<td>HAR36</td>
			<td></td>
		</tr>
		<tr>
			<td>Ligating Clips</td>
			<td>Teleflex Medical</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Nacrotrend anaesthesia monitoring system</td>
			<td>Monitor Technik</td>
			<td>Bad Bramsted</td>
			<td></td>
		</tr>
		<tr>
			<td>Trocar</td>
			<td>Ethicon Endo-Surgery</td>
			<td>10 mm</td>
			<td></td>
		</tr>
	</tbody>
</table>

laparoscopic duodenum-preserving pancreatic head resection via inferior infracolic approach: a surgical approach for benign lesions

Minimally invasive pancreatic resections are gaining popularity despite being technically demanding. However, in contrast to laparoscopic pancreatoduodenectomy (LPD), laparoscopic duodenum-preserving pancreatic head resection (LDPPHR) has not yet obtained wide acceptance. This could be attributed to the technical challenges involved in preserving the blood supply of the duodenum and bile duct.
This study describes and demonstrates all the steps of LDPPHR. A 48-year-old woman was diagnosed with a 3.0 cm x 2.5 cm pancreatic head cystic mass, which was detected unexpectedly. The surgery was performed using the 3D laparoscopy via an inferior infracolic approach. The operation lasted approximately 310 min with 100 mL of blood loss. Postoperatively, the patient experienced no complications and was discharged 5 days later. Pathology revealed intraductal papillary mucinous neoplasms.
LDPPHR via an inferior infracolic approach is feasible and safe when performed by experienced surgeons in selected patients with thin mesenteric fat layers. The described technique for LDPPHR via inferior infracolic approach should be well standardized and performed at high-volume centers with experienced surgeons in both open and laparoscopic pancreatology.

The patient&#39;s total pancreatic head, including the cystic tumor, was removed in 3 h with 100 mL of blood loss. The pancreatojejunal (PJ) anastomosis and jejunal anastomosis were completed in 60 min after the pancreatic head was removed from the body. The entire recovery period after surgery went smoothly, with no signs of postoperative pancreatic fistula. The amylase levels in both drains on postoperative day 3 were 1373 U/L and 804 U/L, respectively, but decreased to normal levels by day 5 when the drains were remov...

Read this Scientific Article Protocol about Laparoscopic Duodenum-Preserving Pancreatic Head Resection via Inferior Infracolic Approach: A Surgical Approach for Benign Lesions at JoVE.com

Laparoscopic Duodenum-Preserving Pancreatic Head Resection via Inferior Infracolic Approach: A Surgical Approach for Benign Lesions

This article provides a whole technical process of laparoscopic duodenum-preserving pancreatic head resection via an inferior infracolic approach. This is a surgical approach for benign tumors without intraoperative fluorescence image guidance.

Minimally invasive pancreatic resections are gaining popularity despite being technically demanding. However, in contrast to laparoscopic ...

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215 조회수.  The Sixth Affiliated Hospital of Sun Yat-sen University. 먼저 복부 복강경 검사를 실시하고 횡결장의 장 지방을 간의 팔시형 인대 위에 매달아 초저주파 구획을 노출시킵니다. 초음파 메스로 십이지장 횡단 중결장 앞쪽을 절개하여 췌장두를 노출시킵니다. 다음으로, 횡결장과 췌장두 사이의 하부구획을 노출시키고 췌장의 uncinate process에서 상장간막 정맥을 완전히 해방시킵니다.클립을 사용하여 지류를 횡단합니다. 이제 초?...