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JoVE Journal

Neuroscience

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Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

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06:45 min

January 19th, 2019

January 19th, 2019

8,822 Views

0:04

Title

0:46

Preparation of Cortical Slices from the Somatosensory-motor Cortex

2:40

Electrophysiological Recordings of the Superficial Cortical Layer and Seizure Induction

4:43

Results: Acute In Vitro 4-AP Cortical Seizure Model and Ictal Events Generated by Optogenetics

6:19

Conclusion

Transcrição

This method can help answer key questions in the study of seizure mechanisms, such as, what neural subpopulations are responsible for electrographic seizure onset and termination. The main advantage of this technique, is that it can reproduce elec

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Acute seizure models are important for studying the mechanisms underlying epileptiform events. Furthermore, the ability to generate epileptiform events on-demand provides a highly efficient method to study the exact sequence of events underlying their initiation. Here, we describe the acute 4-aminopyridine cortical seizure models established in mouse and human tissue.

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