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JoVE Journal

Bioengineering

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Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

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08:26 min

January 21st, 2020

January 21st, 2020

6,591 Views

0:04

Title

1:19

Rapamycin Preparation in Poly (l-lactide)-poly (epsilon-caprolatcone) (PLLA-PCL)

1:56

Rapamycin-Eluting PLLA-PCL Murine Airway Stent Creation

3:08

Laryngotracheal Stenosis Induction

4:50

Transoral PLLA-PCL Stent Placement

5:45

Histologic Sample Preparation

6:26

Results: Representative Tracheal Stent Biocompatibility Assessment

7:23

Conclusion

Transcrição

This protocol lets us investigate drug-eluting stents in a small animal model of laryngotracheal stenosis letting us leverage genetically modified animals in a cost effective manner. Transoral placement of the drug-eluting airway stent spares the

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Laryngotracheal stenosis results from pathologic scar deposition that critically narrows the tracheal airway and lacks effective medical therapies. Using a PLLA-PCL (70% poly-L-lactide and 30% polycaprolactone) stent as a local drug delivery system, potential therapies aimed at decreasing scar proliferation in the trachea can be studied.

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