Preparation of Myelin Oligodendrocyte Glycoprotein Peptide (MOG35-55) Emulsion and Pertussis Toxin
1:55
Establishment of Experimental Autoimmune Encephalomyelitis (EAE) Animal Model
2:55
Open Field Test
3:42
Analysis of Bone Phenotype
4:16
Results: Induction of EAE by MOG35-55 Treatment
5:49
Conclusion
Transcrição
Currently there is no complete cure for multiple sclerosis. Our protocol allows for the effective construction of experimental autoimmune encephalomyelitis model to help explore multiple sclerosis disease therapies. The main advantage of our proto
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The present protocol describes the induction of experimental autoimmune encephalomyelitis in a mouse model using myelin oligodendrocyte glycoprotein and monitoring the disease process using a clinical scoring system. Experimental autoimmune encephalomyelitis-related symptoms are analyzed using mouse femur micro-computed tomography analysis and open field test to assess the disease process comprehensively.