Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

3.3K Views

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06:19 min

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September 9th, 2022

DOI :

10.3791/63866-v

September 9th, 2022

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Chun Wang*¹, Jie Lv*¹, Wei Zhuang¹^,², Ling Xie¹, Guangyu Liu¹, Kaidireya Saimaier¹, Sanxing Han¹, Changjie Shi¹, Qiuhong Hua¹, Ru Zhang¹, Guangfeng Shi³, Changsheng Du¹

¹Putuo People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, ²National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, ³Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University

Summary

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Experimental Autoimmune Encephalomyelitis

Multiple Sclerosis

Myelin Oligodendrocyte Glycoprotein Peptide

Video Analysis System

Chapters in this video

0:04

Introduction

0:44

Preparation of Myelin Oligodendrocyte Glycoprotein Peptide (MOG_35-55) Emulsion and Pertussis Toxin

1:55

Establishment of Experimental Autoimmune Encephalomyelitis (EAE) Animal Model

2:55

Open Field Test

3:42

Analysis of Bone Phenotype

4:16

Results: Induction of EAE by MOG_35-55 Treatment

5:49

Conclusion

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