The overall goal of this murine liver laceration model is to induce uncontrolled hemorrhage for the study of resuscitation practices and the pathophysiologic mechanisms of uncontrolled hemorrhage. This method can help answer key questions in the h
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Uncontrolled hemorrhage, an important cause of mortality among trauma patients, can be modeled using a standard liver laceration in a murine model. This model results in consistent blood loss, survival, and allows for testing hemostatic agents. This article provides the step-by-step process to perform this valuable model.