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Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells

DOI :

10.3791/2514-v

15:41 min

December 2nd, 2010

December 2nd, 2010

17,025 Views

1CYTOO Cell Architects, Grenoble, France, 2Centre Commun de Quantimétrie, Faculté de Médecine Rockefeller, Lyon, France

Adhesive micropatterns that normalize cellular architecture can be used to increase sensitivity in the detection of drug effects, improve reproducibility and simplify automated image acquisition and analysis. Such technology will benefit drug/siRNA screening assays, performed on conventional cell culture supports and consequently suffering from excessive cell-to-cell variability.

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