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Synthesis of an In vivo MRI-detectable Apoptosis Probe

DOI :

10.3791/3775-v

July 31st, 2012

July 31st, 2012

9,017 Views

1Division of Cardiovascular Medicine, Department of Medicine, Stanford University Medical Center, 2Division of Cardiology, Department of Medicine, University of California, San Francisco , 3San Francisco VAMC

Early detection of apoptosis may identify at-risk cell populations in a variety of diseases. Here we demonstrate a method to link an early apoptosis-detection protein (Annexin V) to a MRI-detectable iron oxide nanoparticle (SPIO). This method may be extended to other proteins of interest to generate MRI-detectable molecular imaging probes.

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In Vivo MRI detectable Apoptosis Probe

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