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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

DOI :

10.3791/4246-v

August 19th, 2012

August 19th, 2012

22,980 Views

1Department of Chemistry, Stony Brook University

Adenovirus particles are engineered to contain either the unnatural amino acid analogue azidohomoalanine or the azido sugar O-GlcNAz. The azide group of each is chemoselectively ligated via "click" chemistry reactions as a means of viral surface modification.

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Chemoselective Modification

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