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Granulocyte-dependent Autoantibody-induced Skin Blistering

DOI :

10.3791/4250-v

October 12th, 2012

October 12th, 2012

10,360 Views

1Department of Dermatology, University of Freiburg , 2Kepler High School Freiburg, 3Centre for Biological Signalling Studies (BIOSS), University of Freiburg

In the animal model described in our present work, purified IgG antibodies against a stretch of 200 amino acids (aa 757-967) of collagen VII are injected repeatedly into mice reproducing the blistering phenotype as well as the histo- and immunopathological features characteristic to human epidermolysis bullosa acquisita (EBA)1.

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