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An Orthotopic Bladder Cancer Model for Gene Delivery Studies

DOI :

10.3791/50181-v

December 1st, 2013

December 1st, 2013

11,818 Views

1Department of Microbiology & Immunology, Medical University of South Carolina

Implantation of cancer cells into the organ of origin can serve as a useful preclinical model to evaluate novel therapies. MB49 bladder carcinoma cells can be grown within the bladder following intravesical instillation. This protocol demonstrates catheterization of the mouse bladder for the purpose of tumor implantation and adenoviral delivery.

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