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Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

DOI :

10.3791/50495-v

August 9th, 2013

August 9th, 2013

38,444 Views

1Division of Nephrology, Vanderbilt University Medical Center

We describe models of moderate and severe ischemia-reperfusion-induced kidney injury in which the mice undergo unilateral renal pedicle clamping followed by simultaneous or delayed contralateral nephrectomy, respectively. These models consistently give rise to renal dysfunction and post-injury fibrosis, but injury severity and survival are dependent on mouse background, age and surgical equipment.

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Ischemia reperfusion

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