JoVE Journal

Immunology and Infection

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In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions

To study the interaction of bacteria with the blood vessels under shear stress, a flow chamber and an in vivo mesenteric intravital microscopy model are described that allow to dissect the bacterial and host factors contributing to vascular adhesion.

Chapters in this video

0:05

Title

1:40

S. aureus Preparation for In Vitro Perfusion and In Vivo Experiments

3:00

In Vitro Perfusion Experiments

5:53

In Vivo Mesentric Perfusion Model

8:08

Results: von Willebrand Factor is Essential for Shear Mediated Adhesion of S. aureus to Endothelial Cells and to the Subendothelial Matrix

9:38

Conclusion

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