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Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis

DOI :

10.3791/54852-v

July 29th, 2017

July 29th, 2017

13,386 Views

1Cell, Developmental & Cancer Biology, Oregon Health & Science University, 2University of Minnesota, 3Knight Cancer Institute, Oregon Health & Science University

Pre-clinical models evaluating adjuvant therapy targeting breast cancer metastasis are lacking. To address this, we developed a murine model of de novo pulmonary mammary adenocarcinoma metastasis, wherein therapies administered in the adjuvant setting (post surgical resection of primary tumors) can be evaluated for efficacy in impacting previously seeded pulmonary metastases.

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Surgical Procedures

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