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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

DOI :

10.3791/61173-v

May 18th, 2020

May 18th, 2020

5,207 Views

1Department of Molecular and Cellular Biology, Baylor College of Medicine, 2Lester and Sue Smith Breast Center, Baylor College of Medicine, 3Dan L. Duncan Cancer Center, Baylor College of Medicine

Patient-derived xenograft (PDX) models and transplantable genetically engineered mouse models faithfully recapitulate human disease and are preferred models for basic and translational breast cancer research. Here, a method is described to orthotopically transplant breast tumor fragments into the mammary fat pad to study tumor biology and evaluate drug response.

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Orthotopic Transplantation

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