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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

DOI :

10.3791/58066-v

11:02 min

September 14th, 2018

September 14th, 2018

7,295 Views

1Medical Research Council Laboratory of Molecular Biology

Incorporating a cyclopropene derivative of lysine into antibodies allows the site-specific, rapid and efficient linkage of tetrazine-bearing molecules to generate antibody-drug conjugates.

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Genetic Encoding

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