Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
9.3K Views
•
08:47 min
•
March 6th, 2019
DOI :
March 6th, 2019
•Chapters in this video
0:04
Title
0:28
Synthesis of 4-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-aniline (1)
1:15
Synthesis of Tert-butyl[18-({4-[5-(methylthio)-1,3,4-oxadiazol-2-yl]phenyl}amino)-15,18-dioxo-4,7,10-trioxa-14-azaoctadecyl] Carbamate (2)
3:00
Synthesis of Tert-butyl[18-({4-[5-(methylsulfonyl)-1,3,4-oxadiazol-2-yl]phenyl}amino)-15,18-dioxo-4,7,10-trioxa-14-azaoctadecyl] Carbamate (3)
3:55
Synthesis of N1-(3-{2-[2-(3-aminopropoxy)ethoxy]-ethoxy}propyl)-N4-{4-[5-(methylsulfonyl)-1,3,4-oxadiazol-2-yl] phenyl}Succinamide (PODS)
4:47
Synthesis of PODS-DOTA and Bioconjugation of PODS-DOTA to Trastuzumab
6:05
Results: Synthesis of PODS and PODS-DOTA and Conjugation to Trastuzumab
8:01
Conclusion
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