Multichannel Silicon Probe and Microfluidic Ion Pump (μFIP) Insertion
4:23
Seizure Induction
5:26
Results: Representative Multichannel Recording and Seizure Response Analysis
6:26
Conclusion
Transcript
Our protocol takes advantage of the local administration of the naturally occurring inhibitory neurotransmitter GABA using a very novel device, which could propose a new solution in the treatment of epileptic seizures. The microaerophilic ion pump
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The challenge of epilepsy research is to develop novel treatments for patients where classical therapy is inadequate. Using a new protocol—with the help of an implantable drug delivery system—we are able to control seizures in anesthetized mice by the electrophoretic delivery of GABA into the epileptic focus.