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A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

DOI :

10.3791/63673-v

5:33 min

June 23rd, 2022

June 23rd, 2022

1,936 Views

1Department of Pharmacology and Toxicology, University of Utah, 2Interdepartmental Program in Neuroscience, University of Utah, 3Faculty of Veterinary Medicine, Institute of Pharmacology and Toxicology, Freie Universität Berlin

Intracerebral infection with the Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6 mice replicates many of the early and chronic clinical symptoms of viral encephalitis and subsequent epilepsy in human patients. This paper describes the virus infection, symptoms, and histopathology of the TMEV model.

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Epilepsy

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