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Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

DOI :

10.3791/62929-v

August 17th, 2021

August 17th, 2021

1,981 Views

1Department of Pharmacology, University of Virginia, 2UVA Brain Institute, University of Virginia

This report describes the methods to generate a model of temporal lobe epilepsy based on the electrical kindling of transgenic VGAT-Cre mice. Kindled VGAT-Cre mice may be useful in determining what causes epilepsy and for screening novel therapies.

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Preparation

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