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Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

DOI :

10.3791/59988-v

December 20th, 2019

December 20th, 2019

6,095 Views

1Laboratory of Biology, BIO@SNS, Scuola Normale Superiore

Tau is a neuronal protein present both in the cytoplasm, where it binds microtubules, and in the nucleus, where it exerts unconventional functions including the modulation of Alzheimer's disease-related genes. Here, we describe a method to investigate the function of nuclear Tau while excluding any interferences coming from cytoplasmic Tau.

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