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A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

DOI :

10.3791/61620-v

10:31 min

September 2nd, 2020

September 2nd, 2020

6,878 Views

1Department of Molecular Biology, Massachusetts General Hospital, 2Department of Chemistry, University of Akron, 3Department of Genetics, Harvard Medical School

Mitochondrial fusion is an important homeostatic reaction underlying mitochondrial dynamics. Described here is an in vitro reconstitution system to study mitochondrial inner-membrane fusion that can resolve membrane tethering, docking, hemifusion, and pore opening. The versatility of this approach in exploring cell membrane systems is discussed.

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Membrane Platform

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