Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
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10:53 min
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November 9th, 2020
DOI :
November 9th, 2020
•Benedetta Assetta*1, Changyong Tang*1,2, Jing Bian*3, Ryan O'Rourke1, Kevin Connolly1, Thomas Brickler3, Sundari Chetty3,4, Yu-Wen Alvin Huang1,5,6
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 2Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 5Department of Neurology, Warren Alpert Medical School of Brown University, 6Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University
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Chapters in this video
0:05
Introduction
0:37
Human Neuron Induction from Human Pluripotent Stem Cells
3:59
Human Oligodendrocyte Precursor Cell (OPCs) Induction from Pluripotent Stem Cells and Oligodendrocyte Maturation
7:05
Co-culturing of Human Induced Neurons (Ins) and Oligodendrocyte Precursor Cells (Iopcs)
8:06
Results: Direct Generation of Human Induced Neurons from Human Pluripotent Stem Cells
10:23
Conclusion
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