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DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells

DOI :

10.3791/62348-v

March 20th, 2021

March 20th, 2021

2,273 Views

1Department of Chemistry, Emory University, 2Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

This paper describes a detailed protocol for using DNA-based tension probes to image the receptor forces applied by immune cells. This approach can map receptor forces >4.7pN in real-time and can integrate forces over time.

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